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Pharmacokinetics
Research from University of Udine yields new findings on pharmacokinetics
December 23rd, 2008
"To describe the management of a pharmacokinetic interaction between azole antifungals (fluconazole and voriconazole) and everolimus in a patient who underwent an orthotopic liver transplant. SUMMARY: A 65-year-old male who received an orthotopic liver transplant experienced an iatrogenic retroperitoneal duodenal perforation on postoperative day 55," scientists writing in the journal Annals of Pharmacotherapy report. "His condition was subsequently complicated by severe sepsis and acute renal failure. Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours according to impaired renal function, was immediately started; to avoid further nephrotoxicity,...
Source: TB & Outbreaks Week (2008-12-23)
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