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Bacillus Calmette-Guerin Vaccines
New Bacillus calmette-guerin vaccines research from Food & Drug Administration discussed
December 23rd, 2008
"Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective responses in a murine model of pulmonary tuberculosis, C57BL/6 mice were vaccinated with BCG vaccine and then challenged 2 months later with one of nine M. tuberculosis isolates," scientists in the United States report. "Four of these strains were from the W-Beijing lineage (HN878, N4, NHN5, and ChS) while four were non-Beijing-type isolates (C913, CDC1551,...
Source: TB & Outbreaks Week (2008-12-23)
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