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Life Sciences
Researchers at Federal University release new data on life sciences
December 30th, 2008
According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "ER-119884 and E5700, novel arylquinuclidine derivatives developed as cholesterol-lowering agents, were potent in vitro growth inhibitors of both proliferative stages of Leishmania amazonensis, the main causative agent of cutaneous leishmaniasis in South America, with the 50% inhibitory concentrations (IC(50)s) being in the low-nanomolar to subnanomolar range. The compounds were very potent noncompetitive inhibitors of native L. amazonensis squalene synthase (SQS), with inhibition constants also being in the nanomolar to subnanomolar range." "Growth inhibition was...
Source: TB & Outbreaks Week (2008-12-30)
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