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Tuberculosis
Research from M. Gengenbacher and colleagues has provided new data on tuberculosis
December 30th, 2008
According to a study from Singapore, Singapore, "Dillydropteroate synthase (DHPS) is involved ill de novo biosynthesis of the essential cofactor folate by catalyzing the condensation of para-aminobenzoic acid (pABA) and 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate (H2PtPP). Mycobacterium tuberculosis possesses a functional DHPS (MtDHPS, Rv3608c, folP1) and, based on sequence similarities, a putative ortholog (Rv1207, folP2)." "Here, we demonstrate that Rv1207 shows a low H2PtPP substrate affinity and lacks enzymatic DHPS activity. However, we found dapsone, a structural analog of pABA and clinically used DHPS inhibitor, to weakly bind both proteins. To gain insights...
Source: TB & Outbreaks Week (2008-12-30)
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