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Tuberculosis
Report summarizes tuberculosis study findings from University of Rome, Department of Internal Medicine
December 30th, 2008
Researchers detail in 'A model of phenotypic susceptibility to tuberculosis: deficient in silico selection of Mycobacterium tuberculosis epitopes by HLA alleles,' new data in tuberculosis. "HLA-DR allelic variants have been associated with tuberculosis (TB) susceptibility in different populations with risk ratios of 3.7 to 7.2. We hypothesized that the genetic susceptibility to TB depends upon the reduced capability of HLA-class II alleles of TB patients to bind and select peptide antigen from the Mycobacterium tuberculosis (MTB) expressed genome," scientists writing in the journal Sarcoidosis, Vasculitis, and Diffuse Lung Diseases report. "To test this...
Source: TB & Outbreaks Week (2008-12-30)
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