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Genetics & Genomics
Studies in the area of genetics & genomics reported from Al-Azhar University
January 6th, 2009
"Lomefloxacin is a difluorinated quinolone antibacterial drug. It is widely used against infectious diseases including meningitis, those of the genitourinary and upper respiratory tracts, and skin infections," investigators in Cairo, Egypt report. "Lomefloxacin, like other fluoroquinolones, is mutagenic and the formation of reactive oxygen species appears to be responsible for this genomic instability. The anti-mutagenic effects of naringin, a grapefruit flavonone, against lomefloxacin-induced genomic instability in vivo were evaluated in mouse bone marrow cells by chromosomal aberration and micronucleus (MN) assays. Naringin was neither genotoxic nor cytotoxic in mice...
Source: TB & Outbreaks Week (2009-01-06)
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