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Legionnaire Disease
Study results from A. Tiaden et al provide new insights into legionnaire disease
January 6th, 2009
"The causative agent of Legionnaires' disease, Legionella pneumophila, is a natural parasite of environmental protozoa and employs a biphasic life style to switch between a replicative and a transmissive (virulent) phase. L. pneumophila harbors the lqs (Legionella quorum sensing) cluster, which includes genes encoding the autoinducer synthase LqsA, the sensor kinase LqsS, the response regulator LqsR, and a homologue of HdeD, which is involved in acid resistance in Escherichia coli. LqsR promotes host-cell interactions as an element of the stationary-phase virulence regulatory network," investigators in Zurich, Switzerland report. "Here, we characterize L. pneumophila...
Source: TB & Outbreaks Week (2009-01-06)
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