Legionnaire Disease
Study results from A. Tiaden et al provide new insights into legionnaire disease
Published in TB and Outbreaks Week, January 6th, 2009
"The causative agent of Legionnaires' disease, Legionella pneumophila, is a natural parasite of environmental protozoa and employs a biphasic life style to switch between a replicative and a transmissive (virulent) phase. L. pneumophila harbors the lqs (Legionella quorum sensing) cluster, which includes genes encoding the autoinducer synthase LqsA, the sensor kinase LqsS, the response regulator LqsR, and a homologue of HdeD, which is involved in acid resistance in Escherichia coli. LqsR promotes host-cell interactions as an element of the stationary-phase virulence regulatory network," investigators in Zurich, Switzerland report.
"Here, we characterize L. pneumophila...
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