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Tuberculosis
Reports on tuberculosis findings from R. Vijdea and co-researchers provide new insights
January 6th, 2009
According to a study from Copenhagen, Denmark, "The aim of the present study was to evaluate a new improved multiplex polymerase chain reaction (PCR) hybridisation assay to detect multidrug-resistant tuberculosis. The assay, developed to detect rifampin (rpoB) and isoniazid (katG) gene mutations causing Mycobacterium tuberculosis resistance, was recently extended to include inhA gene mutations that code for low-level isoniazid resistance." "Interpretable results were obtained in 115 isolates and in all smear-positive clinical specimens. Rifampin resistance was correctly identified in all specimens and in 20 of 21 (95%) multidrug-resistant isolates compared to BACTEC...
Source: TB & Outbreaks Week (2009-01-06)
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