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Tuberculosis
Study results from Cornell University in the area of tuberculosis published
January 6th, 2009
"The kinetic pathway of CysM, a cysteine synthase from Mycobacterium tuberculosis, was studied by transient-state kinetic techniques. The expression of which is upregulated under conditions of oxidative stress," investigators in the United States report. "This enzyme exhibits extensive homology with the B-isozymes of the well-studied O-acetylserine sulfhydrylase family and employs a similar chemical mechanism involving a stable a-aminoacrylate intermediate. However, we show that specificity of CysM for its amino acid substrate is more than 500-fold greater for O-phosphO-L-serine than for O-acetyl-L-serine, suggesting that O-phospho-L-serine is the likely substrate in...
Source: TB & Outbreaks Week (2009-01-06)
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