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Tuberculosis
New findings in tuberculosis described from University of Manchester, Faculty of Life Sciences
January 6th, 2009
Research findings, 'Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv,' are discussed in a new report. "Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by gene knock-out with complementation. Production of CYP121 protein in Mtb cells is demonstrated," scientists writing in the Journal of Biological Chemistry report. "Minimum inhibitory concentration values for azole drugs against Mtb H37Rv were determined, the rank order of which correlated well with Kd values for their binding to CYP121....
Source: TB & Outbreaks Week (2009-01-06)
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