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DNA Research
Research reports from Charite University provide new insights into DNA research
January 13th, 2009
According to recent research published in the journal Cellular Microbiology, "Intracellular bacteria and cytosolic stimulation with DNA activate type I IFN responses independently of Toll-like receptors, most Nod-like receptors and RIG-like receptors. A recent study suggested that ZBP1 (DLM-1/DAI) represents the long anticipated pattern recognition receptor which mediates IFN alpha/beta responses to cytosolic DNA in mice." "Here we show that Legionella pneumophila infection, and intracellular challenge with poly(dA-dT), but not with poly(dG-dC), induced expression of IFN beta, full-length hZBP1 and a prominent splice variant lacking the first Z alpha domain...
Source: TB & Outbreaks Week (2009-01-13)
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