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HIV/AIDS Co-Infection
Studies from N. Longley et al have provided new data on HIV/AIDS co-infection
January 13th, 2009
"Therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis in many centers in Africa is fluconazole administered at a dosage of 400-800 mg per day. However, higher dosages of fluconazole have been used to treat patients without resulting in serious toxicity," researchers in Mbarara, Uganda report. "Pharmacokinetic and pharmacodynamic considerations suggest that higher dosages might be associated with greater efficacy. Sixty HIV-seropositive, antiretroviral therapy-naive patients with first-episode cryptococcal meningitis in Mbarara, Uganda, were treated with fluconazole: the first 30 patients received 800 mg per day, and the second 30 patients...
Source: TB & Outbreaks Week (2009-01-13)
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