TB & Outbreaks Week
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Tuberculosis
New findings from M. Skold and co-authors in the area of tuberculosis published
January 13th, 2009
According to a study from Stockholm, Sweden, "The origin and function of the different myeloid cell subsets that appear in the lung during pulmonary tuberculosis are unknown. Herein we show that adoptively transferred monocytes give rise to many of the macrophage and dendritic cell (DC) subsets that appear following aerosol infection with virulent Mycobacterium tuberculosis." "Monocyte differentiation in infected peripheral tissue is surprisingly heterogeneous and results in the formation of five distinct myeloid subsets, including both classically activated macrophages, that produce inducible NO synthase via an ILFN-gamma-dependent mechanism, and DC. In contrast,...
Source: TB & Outbreaks Week (2009-01-13)
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