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TB & Outbreaks Week

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Granuloma



Research on granuloma described by scientists at University of Washington



January 20th, 2009

"Although tuberculous granulomas, which are composed of infected macrophages and other immune cells, have long been considered impermeable structures, recent studies have shown that superinfecting Mycobacterium marinum traffic rapidly to established fish and frog granulomas by host-mediated and Mycobacterium-directed mechanisms," investigators in the United States report.

"The present study shows that superinfecting Mycobacterium tuberculosis and Mycobacterium bovis bacille Calmette-Guerin similarly home to established granulomas in mice. Furthermore, 2 prominent mycobacterial virulence determinants, Erp and ESX-1, do not affect this cellular trafficking," wrote C.L....


Source: TB & Outbreaks Week (2009-01-20)

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