TB & Outbreaks Week
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Life Sciences
Research from University of California broadens understanding of life sciences
January 20th, 2009
According to a study from the United States, "Mycobacterium tuberculosis responds to changes in environmental conditions through a two-component signaling system that detects reduced O-2 tension and NO and CO exposures via the heme-binding GAF domains of two sensory histidine kinases, DosT and DevS, and the transcriptional regulator DosR. We report the first X-ray structure of the DosT heme-bound GAF domain (GAF(DosT)) in both oxy and deoxy forms determined to a resolution of 2.3 angstrom." "In GAF(DosT), heme binds in an orientation orthogonal to that in the PAS domains via a highly conserved motif, including invariant H147 as a proximal heme axial ligand. On the...
Source: TB & Outbreaks Week (2009-01-20)
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