TB & Outbreaks Week
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Tuberculosis
New tuberculosis research from Oregon Health & Science University outlined
January 20th, 2009
"DevS is a heme-based sensor kinase required for sensing environmental conditions leading to nonreplicating persistence in Mycobacterium tuberculosis. Kinase activity is observed when the heme is a ferrous five-coordinate high-spin or six-coordinate low-spin CO or NO complex but is strongly inhibited in the oxy complex," scientists in the United States report. "Discrimination between these exogenous ligands has been proposed to depend on a specific hydrogen bond network with bound oxygen. Here we report resonance Raman data and autophosphorylation assays of wild-type and Y171F DevS in various heme complex-as. The Y171F mutation eliminates ligand discrimination for CO,...
Source: TB & Outbreaks Week (2009-01-20)
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