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HIV/AIDS
Scientists at University of Geneva, Medical Department publish new data on HIV/AIDS
January 27th, 2009
According to recent research from Geneva, Switzerland, "New prevention strategies for use in developing countries are urgently needed to curb the worldwide HIV/AIDS epidemic. The N-terminally modified chemokine PSC-RANTES is a highly potent entry inhibitor against R5-tropic HIV-1 strains, with an inhibitory mechanism involving long-term intracellular sequestration of the HIV coreceptor, CCR5." "PSC-RANTES is fully protective when applied topically in a macaque model of vaginal HIV transmission, but it has 2 potential disadvantages related to further development: the requirement for chemical synthesis adds to production costs, and its strong CCR5 agonist activity might...
Source: TB & Outbreaks Week (2009-01-27)
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