Tuberculosis
Data on tuberculosis detailed by S. Bertholet and co-authors
Published in TB and Outbreaks Week, January 27th, 2009
According to recent research published in the Journal of Immunology, "Development of a subunit vaccine for Mycobacterium tuberculosis (Mtb) depends on the identification of Ags that induce appropriate T cell responses. Using bioinformatics, we selected a panel of 94 Mtb genes based on criteria that included growth in macrophages, up- or down-regulation under hypoxic conditions, secretion, membrane association, or because they were members of the PF/PPE or EsX families."
"Recombinant proteins encoded by these genes were evaluated for IFN-gamma recall responses using PBMCs from healthy subjects previously exposed to Mtb. From this screen, dominant human T cell Ags...
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