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TB & Outbreaks Week

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Plague



Research from University of Exeter reveals new findings on plague



February 3rd, 2009

"The toxin complex (Tc) genes were first identified in the insect pathogen Photorhabdus lurninescens and encode similar to 1 MDa protein complexes which are toxic to insect pests. Subsequent genome sequencing projects have revealed the presence of tc orthologues in a range of bacterial pathogens known to be associated with insects," scientists in Penryn, the United Kingdom report.

"Interestingly, members of the mammalian-pathogenic yersiniae have also been shown to encode Tc orthologues. Studies in Yersinia enterocolitica have shown that divergent tc loci either encode insect-active toxins or play a role in colonization of the gut in gastroenteritis models of rats. So...


Source: TB & Outbreaks Week (2009-02-03)

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