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Tuberculosis
New tuberculosis study results reported from University of Minnesota
February 10th, 2009
"The synthesis, biochemical, and biological evaluation of a systematic series of 2-triazole derivatives of 5'-O-[N-(salicyl)sulfamoyl]adenosine (Sal-AMS) are described as inhibitors of aryl acid adenylating enzymes (AAAE) involved in siderophore biosynthesis by Mycobacterium tuberculosis," scientists writing in the Journal of Medicinal Chemistry report. "Structure-activity relationships revealed a remarkable ability to tolerate a wide range of substituents at the 4-position of the triazole moiety, and a majority of the Compounds possessed subnanomolar apparent inhibition constants. However, the in vitro potency did not always translate into whole cell biological...
Source: TB & Outbreaks Week (2009-02-10)
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