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Central Nervous System Infection
Studies in the area of central nervous system infection reported from New York University
February 10th, 2009
"Lymphocytic choriomeningitis virus(1) infection of the mouse central nervous system (CNS) elicits fatal immunopathology through blood - brain barrier breakdown(2) and convulsive seizures(3). Although lymphocytic- choriomeningitis- virus- specific cytotoxic T lymphocytes ( CTLs) are essential for disease(4), their mechanism of action is not known," scientists in the United States report. "To gain insights into disease pathogenesis, we observed the dynamics of immune cells in the meninges by two-photon microscopy. Here we report visualization of motile CTLs and massive secondary recruitment of pathogenic monocytes and neutrophils that were required for vascular leakage...
Source: TB & Outbreaks Week (2009-02-10)
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