Tuberculosis

Research from Fudan University in the area of tuberculosis described

Published in TB and Outbreaks Week, February 17th, 2009

According to recent research from Shanghai, People's Republic of China, "Tuberculosis (TB) continues to be a major cause of morbidity and mortality worldwide. The increasing emergence and spread of drug-resistant TB poses a significant threat to disease control and calls for the urgent development of new drugs."

"The tryptophan biosynthetic pathway plays an important role in the survival of Mycobacterium tuberculosis. Thus, indole-3-glycerol phosphate synthase (IGPS), as an essential enzyme in this pathway, might be a potential target for anti-TB drug design. In this study, we deduced the structure of IGPS of M. tuberculosis H37Rv by using homology modeling. On the...

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Source: TB and Outbreaks Week (2009-02-17)

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