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Edema
New edema study results from P.J. Chou et al described
February 17th, 2009
"Bacillus anthracis produces lethal toxin (LT) and edema toxin (ET), and they suppress the function of LPS-stimulated dendritic cells (DCs). Because DCs respond differently to various microbial stimuli, we compared toxin effects in bone marrow DCs stimulated with either LPS or Legionella pneumophila (Lp)," scientists in the United States report. "LT, not ET, was more toxic for cells from BALB/c than from C57BL/6 (B6) as measured by 7-AAD uptake; however, ET suppressed CD11c expression. LT suppressed IL-12, IL-6, and TNF-alpha in cells from BALB/c and B6 mice but increased IL-1 beta in LPS-stimulated cultures. ET also suppressed IL-12 and TNF-alpha, but increased IL- 6...
Source: TB & Outbreaks Week (2009-02-17)
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