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Enzyme Research
Research from A.K. Bergfeld and co-authors yields new data on enzyme research
February 24th, 2009
According to recent research from Hannover, Germany, "Neisseria meningitidis serogroup C is a major cause of bacterial meningitis and septicaemia. This human pathogen is protected by a capsule composed of alpha 2,9-linked polysialic acid that represents an important virulence factor." "In the majority of strains, the capsular polysaccharide is modified by O-acetylation at C-7 or C-8 of the sialic acid residues. The gene encoding the capsule modifying O-acetyltransferase is part of the capsule gene complex and shares no sequence similarities with other proteins. Here, we describe the purification and biochemical characterization of recombinant OatC. The enzyme was found...
Source: TB & Outbreaks Week (2009-02-24)
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