TB & Outbreaks Week
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Severe Acute Respiratory Syndrome
Studies from J. Yang and colleagues provide new data on severe acute respiratory syndrome
February 24th, 2009
"Identification of dominant T cell epitopes within newly emerging and re-emerging infectious organisms is valuable in understanding pathogenic immune responses and potential vaccine designs. However, difficulties in obtaining samples from patients or convalescent subjects have hampered research in this direction," investigators in the United States report. "We demonstrated a strategy, tetramer-guided epitope mapping, that specific CD4+ T cell epitopes can be identified by using PBMC from subjects that have not been exposed to the infectious organism. Sixteen HLA-DR0401- and 14 HLA-DR0701-restricted epitopes within spike protein of severe acute respiratory...
Source: TB & Outbreaks Week (2009-02-24)
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