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DNA Vaccines
Scientists at Fourth Military Medical University target DNA vaccines
March 3rd, 2009
According to recent research from Xian, People's Republic of China, "Developing a new generation of vaccines is important for preventing tuberculosis (TB). DNA vaccine is one promising candidate." "In this study we evaluated the immunogenicity and protective efficacy of the DNA vaccine encoding the fusion protein of Mycobacterium tuberculosis heat shock protein 65 (Hsp65) with human interleukin-2 (hIL-2) in BALB/c mice. We showed that the DNA vaccine pcDNA-Hsp65-hIL-2 could induce high levels of antigen-specific antibody, IFN-gamma, CD4(+) and CD8(+) T cell production. When the immunized mice were infected with M. tuberculosis H37Rv, the organ bacterial loads in the DNA...
Source: TB & Outbreaks Week (2009-03-03)
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