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Tuberculosis
New tuberculosis research reported from O.H. Vandal and co-authors
March 3rd, 2009
"Mycobacterium tuberculosis can persist in macrophage phagosomes that acidify to a pH of similar to 4.5 after activation of the macrophage with gamma interferon. How the bacterium resists the low pH of the acidified phagosome is incompletely understood," scientists in the United States report. "A screen of 10,100 M. tuberculosis transposon mutants for mutants hypersensitive to pH 4.5 led to the discovery of 21 genes whose disruption attenuated survival of M. tuberculosis at a low pH (41). Here, we show that acid-sensitive M. tuberculosis mutants with transposon insertions in Rv2136c, Rv2224c, ponA2, and lysX were hypersensitive to antibiotics, sodium dodecyl sulfate,...
Source: TB & Outbreaks Week (2009-03-03)
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