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Tuberculosis
Research from F. Brossier and co-authors yields new data on tuberculosis
March 3rd, 2009
According to recent research from Paris, France, "We recently evaluated the Genotype (R) MTBDR test for assessing Mycobacterium tuberculosis resistance to rifampicin (RMP) and isoniazid (INH) by detecting mutations in rpoB (codons 511-533) and katG (codon 315). A new version of the test, MTBDR plus, has been designed to also detect mutations in the regulatory region of inhA." "To evaluate the performance of MTBDR plus over MTBDR. In 113 isolates, MTBDR plus detected all 76 RMP-resistant (RMP-R) strains and all 64 INH-resistant (INH-R) strains with KatG-315 mutations, 59 of which displayed a high level of INH resistance. It also identified 18 strains undetectable by...
Source: TB & Outbreaks Week (2009-03-03)
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