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Hemorrhagic Fever
Data from M. Simon et al provide new insights into hemorrhagic fever
March 10th, 2009
"To date, the entry pathway and replication mechanisms for members of the family Bunyaviridae, and especially for Crimean-Congo hemorrhagic fever virus (CCHFV), are poorly understood. Considering the severity of disease and the widespread geographical occurrence of CCHFV, investigating viral entry is of great value for development of antivirals," investigators in Stockholm, Sweden report. "In this study, we have shown that knockdown of clathrin by small interfering RNA significantly reduced CCHFV nucleocapsid protein and viral RNA levels, suggesting that CCHFV utilizes clathrin-dependent endocytosis. In contrast, caveolin-1, an important constituent of caveolae...
Source: TB & Outbreaks Week (2009-03-10)
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