TB & Outbreaks Week
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Life Sciences
Reports outline life sciences research from A.I. Iliev and colleagues
March 10th, 2009
"Streptococcus pneumoniae is the most frequent cause of bacterial meningitis, leading to permanent neurological damage in 30% and lethal outcome in 25% of patients. The cholesterol-dependent cytolysin pneumolysin is a major virulence factor of S. pneumoniae," scientists in Germany report. "It produces rapid cell lysis at higher concentrations or apoptosis at lower concentrations. Here, we show that sublytic amounts of pneumolysin produce rapid bundling and increased acetylation of microtubules (signs of excessive microtubule stabilization) in various types of cells - neuroblastoma cells, fibroblasts and primary astrocytes. The bundling started perinuclearly and extended...
Source: TB & Outbreaks Week (2009-03-10)
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