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Mycobacteria
Researchers from Case Western Reserve University report recent findings in mycobacteria
March 10th, 2009
"Mycobacterium tuberculosis and M. bovis BCG infect APCs. In vitro, mycobacteria inhibit IFN-gamma-induced MHC-II expression by macrophages, but the effects of mycobacteria on lung APCs in vivo remain unclear," scientists in the United States report. "To assess MHC-II expression on APCs infected in vivo, mice were aerosol-infected with GFP-expressing BCG. At 28 cl, similar to 1% of lung APCs were GFP+ by flow cytometry and CFU data. Most GFP+ cells were CD11b(high)/CD11c(neg-mid) lung macrophages (58-68%) or CD11b(high)/CD11c(high) DCs (28-31%). Lung APC MHC-II expression was higher in infected mice than naive mice. Within infected lungs, however, MHC-II expression was...
Source: TB & Outbreaks Week (2009-03-10)
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