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Tuberculosis
Research on tuberculosis described by Z.Q. Yuan and colleagues
March 10th, 2009
According to recent research published in the Journal of Immunology, "The possibility that mycobacterial infections induce variant cytokine mRNA encoding a functionally distinct protein for immune regulation has not been addressed. In this study, we reported that Mycobacterium tuberculosis and bacillus Calmette-Guerin infections of macaques induced expression of variant IL-4 (VIL-4) mRNA encoding a protein comprised of N-terminal 97 aa identical with IL-4, and unique C-terminal 96 aa including a signaling-related proline-rich motif." "While VIL-4 could be stably produced as intact protein, the purified VIL-4 induced apparent expansion of phosphoantigen...
Source: TB & Outbreaks Week (2009-03-10)
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