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Tuberculosis
Research on tuberculosis detailed by scientists at University of Manchester
March 10th, 2009
"Mycobacterium tuberculosis FprA (flavoprotein reductase A) is,in NAD(P)H- and FAD-binding reductase that is structurally/ evolutionarily related to adrenodoxin reductase. Structural in interactions with the analysis implicates Arg(199) and Arp(200) NADP(H) 2'-phosphate group," scientists in Manchester, the United Kingdom report. "R199A, R200A and R199A/ R200A Mutants were characterized to explore the roles of these basic residues. All Mutations abolished neutral FAD semiquinone stabilization in the NADPH-reduced enzyme, owing to weakened NADPH affinity. Instead, FAD hydroquinone was formed in all mutants, and each displayed Substantially enhanced autooxidation rates...
Source: TB & Outbreaks Week (2009-03-10)
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