Legionnaire Disease

Scientists at Tufts University, Medical Department detail research in legionnaire disease

Published in TB and Outbreaks Week, March 17th, 2009

"The bacterial pathogen Legionella pneumophila replicates in a specialized vacuole within host cells. Establishment of the replication vacuole depends on the Dot/Icm translocation system that delivers a large number of protein substrates into the host cell," investigators in the United States report.

"The functions of most substrates are unknown. Here, we analysed a defined set of 127 confirmed or candidate Dot/Icm substrates for their effect on host cell processes using yeast as a model system. Expression of 79 candidates caused significant yeast growth defects, indicating that these proteins impact essential host cell pathways. Notably, a group of 21 candidates...

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Source: TB and Outbreaks Week (2009-03-17)

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