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Tuberculosis Genetics
Research from Ecole polytechnique federale de Lausanne in the area of tuberculosis genetics described
March 17th, 2009
Data detailed in 'Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis' have been presented. "Comparative genomics with Staphylococcus aureus suggested the existence of a regulatory system governing beta-lactamase (BlaC) production in Mycobacterium tuberculosis. The crystal structure of Rv1846c, a winged helix regulator of previously unknown function, was solved thus revealing strong similarity to the BlaI and MecI repressors of S. aureus, which both respond to beta-lactam treatment," scientists in Lausanne, Switzerland report. "Using chromatin immunoprecipitation and hybridization to microarrays...
Source: TB & Outbreaks Week (2009-03-17)
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