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Ebola Hemorrhagic Fever
Findings from University of Pennsylvania, Medical Department broaden understanding of ebola hemorrhagic fever
March 24th, 2009
According to a study from the United States, "Ebola virus causes an acute hemorrhagic fever that is associated with high morbidity and mortality. The viral glycoprotein is thought to contribute to pathogenesis, though precise mechanisms are unknown." "Cellular pathogenesis can be modeled in vitro by expression of the Ebola viral glycoprotein (GP) in cells, which causes dramatic morphological changes, including cell rounding and surface protein down-regulation. These effects are known to be dependent on the presence of a highly glycosylated region of the glycoprotein,the mucin domain. Here we show that the mucin domain from the highly pathogenic Zaire subtype of Ebola...
Source: TB & Outbreaks Week (2009-03-24)
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