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Life Sciences
Report summarizes life sciences study findings from University of Toulouse
March 24th, 2009
"A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of Leishmania amazonensis in axenical cultures and murine infected macrophages," scientists in Toulouse, France report. "Structure-activity relationships demonstrated the importance of a radical methoxy at position R-3', R-4' and R-5'. (2E)-3-(3,4,5-trimethoxy-phenyl)-1-(3,6,7-trimethyl-1,4-dioxy-quinoxalin-2- yl)-propenone was the most active," wrote A. Burguete and colleagues, University of Toulouse. The researchers concluded: "Cytotoxicity on macrophages revealed...
Source: TB & Outbreaks Week (2009-03-24)
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