TB & Outbreaks Week
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Tuberculosis
New tuberculosis study findings have been reported from W.P. Gill et al
March 24th, 2009
"Few tools exist to assess replication of chronic pathogens during infection. This has been a considerable barrier to understanding latent tuberculosis, and efforts to develop new therapies generally assume that the bacteria are very slowly replicating or nonreplicating during latency(1-3)," scientists writing in the journal Nature Medicine report. "To monitor Mycobacterium tuberculosis replication within hosts, we exploit an unstable plasmid that is lost at a steady, quantifiable rate from dividing cells in the absence of antibiotic selection. By applying a mathematical model, we calculate bacterial growth and death rates during infection of mice. We show that...
Source: TB & Outbreaks Week (2009-03-24)
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