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Pandemics



Scientists at University of Wisconsin, Medical Department target pandemics



March 31st, 2009

"The 1918 influenza pandemic was the most devastating outbreak of infectious disease in human history, accounting for about 50 million deaths worldwide. In addition to a significant number of cases of secondary bacterial pneumonia, this highly pathogenic strain of influenza A virus caused fatal primary viral pneumonia," scientists in the United States report.

"To identify the viral gene(s) chiefly responsible for the high virulence of the 1918 virus, we generated a series of reassortants between the 1918 virus and a contemporary human H1N1 virus (A/Ka-wasaki/173/2001; K173) using reverse genetics. We then assessed their virulence properties in ferrets, a model closely...


Source: TB & Outbreaks Week (2009-03-31)

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