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Plague
Research from University of Illinois provides new data on plague
March 31st, 2009
"Interleukin-10 (IL-10)-deficient mice are resistant to several pathogens, including Yersinia pestis. Surprisingly, we observed that heterozygous IL-10(+/-) mice also survive high-dose intravenous infection with Y. pestis KIM5 (Pgm(-))," scientists in the United States report. "Analysis of commercial IL-10(+/-) mice revealed that at least 30 cM of genomic DNA from the original 129 strain remains, including a functional Slc11a1 (Nramp1) gene. Interestingly, two substrains of 129 mice were resistant to high-dose Y. pestis KIM5. Resistance does not appear to be recessive, as F-1 mice (C57BL/6J X 129) also survived a high-dose challenge. A QTL-based genetic scan of...
Source: TB & Outbreaks Week (2009-03-31)
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