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Tuberculosis
Reports from Johns Hopkins University describe recent advances in tuberculosis
March 31st, 2009
"The rabbit model of tuberculosis is attractive because of its pathophysiologic resemblance to the disease in humans. Rabbits are naturally resistant to infection but may manifest cavitary lung lesions," scientists in the United States report. "We describe here a novel approach that utilizes presensitization and bronchoscopic inoculation to reliably produce cavities in the rabbit model. With a fixed inoculum of bacilli, we were able to reproducibly generate cavities by using Mycobacterium bovis Ravenel, M. bovis AF2122, M. bovis BCG, M. tuberculosis H37Rv, M. tuberculosis CDC1551, and the M. tuberculosis CDC1551 Delta sigC mutant. M. bovis infections generated cavitary...
Source: TB & Outbreaks Week (2009-03-31)
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