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TB & Outbreaks Week

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Bird Flu



New bird flu research from J. Steel et al outlined



March 31st, 2009

"Due to the high mortality associated with recent, widely circulating strains of H5N1 influenza virus in poultry, the recurring introduction of H5N1 viruses from birds to humans, and the difficulties in H5N1 eradication by elimination of affected flocks, an effective vaccine against HPAI (highly pathogenic avian influenza) is highly desirable. Using reverse genetics, a set of experimental live attenuated vaccine strains based on recombinant H5N1 influenza virus A/Viet Nam/1203/04 was generated," scientists in the United States report.

"Each virus was attenuated through expression of a hemagglutinin protein in which the polybasic cleavage site had been removed. Viruses...


Source: TB & Outbreaks Week (2009-03-31)

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