Legionnaire Disease Cell Biology
Institute of Microbiology details research in legionnaire disease cell biology
Published in TB and Outbreaks Week, March 31st, 2009
A new study, 'The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE,' is now available. "Legionella pneumophila, the causative agent of Legionnaires' disease, replicates within a specific vacuole in amoebae and macrophages. To form these 'Legionella-containing vacuoles' (LCVs), the bacteria employ the Icm/Dot type IV secretion system and effector proteins, some of which anchor to the LCV membrane via the host glycolipid phosphatidylinositol 4-phosphate [PtdIns(4)P]," scientists in Zurich, Switzerland report.
"Here we analysed the role of inositol...
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