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Enzyme Research
Studies by J.J. Osterholzer and co-authors describe new findings in enzyme research
April 7th, 2009
"Urease, a major virulence factor for Cryptococcus neoformans, promotes lethal meningitis/encephalitis in mice. The effect of urease within the lung, the primary site of most invasive fungal infections, is unknown," scientists in the United States report. "An established model of murine infection that utilizes either urease-producing (wt and ure1::URE1) or urease-deficient (ure1) strains (H99) of C neoformans was used to characterize fungal clearance and the resultant immune response evoked by these strains within the lung. Results indicate that mice infected with urease-producing strains of C neoformans demonstrate a 100-fold increase in fungal burden beginning 2 weeks...
Source: TB & Outbreaks Week (2009-04-07)
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