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Leishmaniasis
Studies from R. Khouri and co-researchers in the area of leishmaniasis published
April 7th, 2009
"Type I IFNs (IFN-alpha/beta) have only recently gained considerable attention as immunomodulators in nonviral infectious diseases. IFN-beta has been shown to protect, in a NO-dependent manner, against murine Old World leishmaniasis caused by Leishmania major, but data in New World leishmaniasis are lacking," scientists writing in the Journal of Immunology report. "We found that IFN-beta dose-dependently increases parasite burden in Leishmania amazonensis- as well as Leishmania braziliensis-infected human macrophages, independent of endogenous or exogenous NO. However, IFN-beta significantly reduced superoxide release in Leishmania-infected as well as uninfected...
Source: TB & Outbreaks Week (2009-04-07)
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