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Life Sciences
Research from I. Hernandezvaldepena and co-authors yields new data on life sciences
April 7th, 2009
"Clofazimine, an antibiotic drug active against mycobacteria and used for the treatment of leprosy, is a very weak base insoluble in neutral aqueous media. it may cause rather severe secondary effects. Basically, these two shortcomings can be minimized by combination with a drug carrier," researchers in Montpellier, France report. "The potential of a polymeric carrier composed of nanosized aggregates formed by hydrophobized poly(methyl vinyl ether-alt-maleic acid) to solubilize clofazimine in neutral aqueous media and to administer it to mice was investigated. This amphiphilic polyanion was synthesized by partial esterification of commercial poly(methyl vinyl...
Source: TB & Outbreaks Week (2009-04-07)
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