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Tuberculosis
New tuberculosis study findings reported from University of California
April 7th, 2009
According to recent research from the United States, "During the initial growth infection stage of Mycobacterium tuberculosis (Mtb), (NO)-N-center dot produced by host macrophages inhibits heme-containing terminal cytochrome oxidases, inactivates iron/sulfur proteins, and promotes entry into latency. Here we evaluate the potential of (NO)-N-center dot as an inhibitor of Mtb cytochrome P450 enzymes, as represented by CYP130, CYP51, and the two previously uncharacterized. enzymes CYP125 and CYP142." "Using UV-visible absorption, resonance Raman, and stopped-flow spectroscopy, we investigated the reactions of (NO)-N-center dot with these heme proteins in their ferric...
Source: TB & Outbreaks Week (2009-04-07)
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