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Tuberculosis
Research results from P. England and co-authors update knowledge of tuberculosis
April 7th, 2009
According to recent research published in the journal Febs Letters, "Fork-head associated (FHA) domains are widely found in bacteria, but their cellular functions remain unclear. Here, we focus on Mycobacterium tuberculosis GarA, an FHA-containing protein conserved in actinomycetes that is phosphorylated by different Ser/Thr protein kinases." "Using various physicochemical approaches, we show that phosphorylation significantly stabilizes GarA, and that its FHA domain interacts strongly with the phosphorylated N-terminal extension. Altogether, our results indicate that phosphorylation triggers an intra-molecular protein closure, blocking the...
Source: TB & Outbreaks Week (2009-04-07)
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