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Drug Resistance
Investigators at University of Wurzburg target drug resistance
April 14th, 2009
According to recent research from Wurzburg, Germany, "Alternative drugs against leishmaniasis are desperately needed. Antimonials, the main chemotherapeutic tool, cause serious side effects and promote chemoresistance." "We previously demonstrated that representatives of N,C-linked arylisoquinolines are promising leishmanicidal drug candidates. We now performed structure-activity relationship studies varying the aryl portion of our lead substrate. The new series of compounds show an enhanced selectivity against Leishmania mayor in comparison to their major host cell, the macrophage. Our results suggest that the arylisoquinolinium salts decrease the macrophage infection...
Source: TB & Outbreaks Week (2009-04-14)
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