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Legionnaire Disease
Research conducted at E. Brombacher and co-authors has provided new information about legionnaire disease
April 21st, 2009
"The causative agent o f Legionnaires disease, Legionella pneumophila, forms a replicative vacuole in phagocytes by means of the intracellular multiplication/defective organelle trafficking (Icm/Dot) type IV secretion system and translocated effector proteins, some of which subvert host GTP and phosphoinositide (PI) metabolism. The Icm/Dot substrate SidC anchors to the membrane of Legionella-containing vacuoles (LCVs) by specifically binding to phosphatidylinositol 4-phosphate (PtdIns(4) P)," scientists in Zurich, Switzerland report. "Using a nonbiased screen for novel L. pneumophila PI-binding proteins, we identified the Rab1 guanine nucleotide exchange factor (GEF)...
Source: TB & Outbreaks Week (2009-04-21)
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